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Therapies to induce immune responses against tumors, such as anti-PD-1 antibodies, have revolutionized the treatment of many cancers. TNF is a key mediator of bone loss, not only through promotion of osteoclasts (bone-resorbing cells), but also through inhibition of osteoblast (bone-forming cells) function. Presented at: ACR Convergence 2020; November 5-9, 2020. Sign in Their observation suggests that synovial endothelial cells, rather than being passive conduits of blood flow, orchestrate tissue remodeling through secretion of paracrine morphogenic signals. If it is more severe and there is involvement of numerous joints with polyarticular inflammation and skin involvement, you directly use a TNF inhibitor and avoid methotrexate. Drs. Zheni Stavre, MD; JungMin Kim, PhD; Jae-Hyuck Shim, PhD; Ellen M. Gravallese, MD. Enjoying our content? Presented at: ACR Convergence 2020; November 5-9, 2020. Full Schedule - ACR Convergence 2020; Full Schedule - ACR Convergence 2020. Registration is free. This site features news for physicians about research, innovation and clinical care at Brigham and Women’s Hospital. The study found no difference between the combination treatment and etanercept alone. We hope you’re enjoying the latest clinical news, full-length features, case studies, and more. Kiniksa Announces American College of Rheumatology Convergence 2020 Late-Breaking Abstracts Presentation of Mavrilimumab Phase 2 Giant Cell … Favorites; Login; Register; View and print all favorites; Clear all your favorites; Meeting Resource Center; Abstract Number: 0403. A Delphi consensus study to standardize terminology for the pre-clinical phase of psoriatic arthritis. Disclosure: Dr Atul A. Deodhar declared affiliations with the pharmaceutical industry. Coates L, Gladman D, Van de Bosch F, et al. November 5-9, 2020… There were 2 parts to this study: the first was at year 1 when patients developed PsA after they were initiated into the study, and the second was at year 5. November 5-9, 2020… The SELECT – PsA 1 study also included adalimumab as a comparator. There is a hierarchy to follow depending on the severity of the patient’s PsA. ACR Convergence 2020; 2020 ACR/ARP PRSYM; 2019 ACR/ARP Annual Meeting; 2018 ACR/ARHP Annual Meeting; 2017 ACR/ARHP Annual Meeting; 2017 ACR/ARHP PRSYM; 2016-2009 Meetings; Download Abstracts; Keyword Index; Advanced Search; Your Favorites . Important Dates . Pages: 1-4231; First Published: 09 November 2020; Abstract; PDF; Request permissions; Tools. JAK inhibitors have been approved for the treatment of rheumatoid arthritis (RA), and we know that they are fairly good with respect to the peripheral joints because of our experience with them in RA. Abstract 2025. However, there are several clinical, genetic, and radiographic differences between axial PsA and axial SpA, and this is an active area of research. So, this is another new and interesting class of drugs that we can look forward to. We are now also observing that guselkumab, at least according to the results of DISCOVER-1 (ClinicalTrials.gov Identifier: NCT03162796) and DISCOVER-2 (ClinicalTrials.gov Identifier: NCT03158285) trials, has been found to have a strikingly good safety profile. In this study, the team performed single-cell transcriptomic analysis (scRNAseq) of synovial vasculature to characterize vascular remodeling at a single-cell level. Abstract 907. The study highlights the power of single-cell transcriptomics in identifying cellular and molecular changes in organ tissues affected by inflammatory diseases. … ET. Get stock quotes, news, fundamentals and easy to read SEC and SEDI insider filings. This is where the treatment guidelines are very important. If you wish to read unlimited content, please log in or register below. In the United States, unfortunately, treatment also depends on what the insurance company will approve and patients’ out-of-pocket expenses. All times listed are Eastern Standard Time. Favorites; Login; Register; View and print all favorites; Clear all your favorites; Meeting Resource Center; Welcome to the ACR/ARP Abstracts … Presented at: ACR Convergence 2020; November 5-9, 2020. Neither of these agents was found to be effective in patients with axial spondyloarthritis (SpA). The ACR abstracts are available online at the conference website. All Days; Fri, Nov 6 ; Full Schedule - 2020 ACR Convergence. There was another presentation at ACR 2020 on whether there are risk factors in patients with skin psoriasis who develop PsA. Information from the ACR presentations are under embargo until November 5, 2020 at 2:00 p.m. They assessed changes in BASDAI (Bath Ankylosing Spondylitis Disease Activity Index), and, when guselkumab was compared to placebo, there was a statistically significant difference. In clinical practice, my decision will depend on how severe the patient’s musculoskeletal disease and skin disease are. ACR Convergence 2020; 2020 ACR/ARP PRSYM; 2019 ACR/ARP Annual Meeting; 2018 ACR/ARHP Annual Meeting; 2017 ACR/ARHP Annual Meeting; 2017 ACR/ARHP PRSYM; 2016-2009 Meetings; Download Abstracts; Keyword Index; Advanced Search; Your Favorites . The ACR abstracts are available online at the conference website.Information from the ACR presentations are under embargo until November 5, 2020 at 2:00 p.m. Norwood, MA, Oct. 21, 2020 (GLOBE NEWSWIRE) -- Corbus Pharmaceuticals Holdings, Inc. (NASDAQ: CRBP) (“Corbus” or the “Company”), a clinical-stage drug development company pioneering transformative medicines that target the endocannabinoid system, today announced the presentation of three abstracts at the American College of Rheumatology (“ACR”) Convergence 2020 being held … We were surprised to find the efficacy of Janus kinase (JAK) inhibitors on the skin. Efficacy and safety of deucravacitinib (BMS-986165), an oral, selective tyrosine kinase 2 inhibitor, in patients with active psoriatic arthritis: results from a phase 2, randomized, double-blind, placebo-controlled trial. Watts, MSc; Trinn Major, PhD; Zhu, MSc; Yuhong Li, MSc; Christopher Buckley, MBBS; Soumya Raychaudhuri, MD, PhD; Michael B. Brenner, MD. Copyright © 2020 Haymarket Media, Inc. All Rights Reserved There are some really interesting poster and abstract presentations on spondyloarthritis at the ACR Convergence 2020. “We hope that by understanding the similarities and differences between immune cells in different types of inflammatory arthritis, including checkpoint inhibitor-associated arthritis, we can identify specific signals that block the key pathologic signals in each condition,” Dr. Rao said. The ACR and NPF guidelines are very practical, and they answer exactly this question. So, symmetric vs asymmetric sacroiliitis and thin vs chunky syndesmophytes would be 1 way of differentiating between axial PsA and axial SpA. If treatment with the TNF inhibitor fails, the class could be changed if it were a primary failure, and it can remain in the same class if it were a secondary failure. There are also several types of drugs and there are many different classes of each drug: conventional synthetic disease-modifying antirheumatic drugs (DMARDs); TNF inhibitors (there are 5 of them); the IL-12/23 inhibitor (ustekinumab); IL-17 inhibitors (secukinumab and ixekizumab); pure IL-23 inhibitors (there are 3 of them; 1 has been approved for PsA [guselkumab], but rizankizumab and tildrakizumab are being studied in phase 2 trials presented at the ACR 2020 meeting); JAK inhibitors; the phosphodiesterase-4 (PDE4) inhibitor apremilast; and abatacept (a T-cell inhibitor that is mainly used for RA but has been approved for the treatment of PsA). Mease P, Helliwell P, Gladwell D, et al. The researchers indicated that methotrexate seems to have good efficacy in PsA, although the study had limitations because there was no placebo and it could be claimed that the methotrexate response was because of the placebo. Program and Faculty are updated daily - check back often for the most up-to-date information. Michael B. Brenner, MD, was named an ACR Master, which recognizes “outstanding contributions to the ACR and the field of rheumatology through scholarly achievement and/or service to their patients, students, and profession.” In addition, Daniel Hal Solomon, MD, MPH, was given the Excellence in Investigative Mentoring Award, which honors “contributions to the rheumatology profession through outstanding and ongoing mentoring.”. There were many studies that addressed “pre-PsA,” similar to pre-RA in patients with some arthralgias and a positive cyclic citrullinated peptide (CCP) test. Favorites; Login; Register; View and print all favorites; Clear all your favorites; Meeting Resource Center; ACR Convergence 2020 . Favorites; Login; Register; View and print all favorites; Clear all your favorites; Meeting Resource Center; Abstract Number: 1460 “Can I … These analyses identified enrichment of Notch receptor activation among arterial endothelial cells and a subset of capillaries, implicating Notch signaling during vascular remodeling in RA. ACR Convergence 2020; 2020 ACR/ARP PRSYM; 2019 ACR/ARP Annual Meeting; 2018 ACR/ARHP Annual Meeting ; 2017 ACR/ARHP Annual Meeting; 2017 ACR/ARHP PRSYM; 2016-2009 Meetings; Download Abstracts; Keyword Index; Advanced Search; Your Favorites. With Phase 2 of the Accelerating Medicines Partnership (AMP) study of systemic lupus erythematosus (SLE) underway, an ACR Convergence 2020 session featured a panel that reviewed the methods being used to generate data and discussed some of the findings and insight gained from ongoing analyses of kidney and urine. Accepted general abstracts from ACR Convergence 2020 can be searched and viewed online starting late September. These cells are highly activated and are equipped to kill target cells. Ashvattha Therapeutics, a clinical-stage biotech company focused on … This totals to up to as many as 12 different targeted novel molecules that we have for the treatment of PsA, so it has become a fairly rich field of treatment options besides the usual conventional synthetic DMARDs. Investigators examined whether iCMP was effective at decreasing the incidence rates of ED visits, hospitalizations and outpatient appointment no-shows. Abstract 907. Dr. Liao’s team developed an algorithm using machine learning and NLP that reduced the number of charts requiring review by 40–45 percent compared to reviewing any subjects with an ICD code for rheumatoid arthritis (RA). Full Schedule - ACR Convergence 2020; Full Schedule - ACR Convergence 2020. here. In clinical practice, I believe that this distinction may not matter that much, as both TNF and IL-17 inhibitors would probably work on both conditions. - Full-Length Features If the disease is mild, you can use methotrexate. McInnes I, Anderson JK, Magrey M, et al. In axial PsA, patients typically have asymmetric sacroiliitis and “chunky,” asymmetric, osteophyte-looking changes in the spine that run from the middle of the vertebra to the next vertebra. A nurse-led integrated care management program (iCMP) aims to coordinate medical care and to uncover and address social determinants of health-related needs for medically and psychosocially complex patients at high risk for frequent emergency department visits and hospitalizations. Here is a flavour of my read through … These investigators recently reported that a key step in pannus formation and fibroblast expansion in RA is driven by endothelial-derived Notch signaling. Accepted Late-Breaking abstracts will be available late October. For the first time, ACR Convergence 2020 was a virtual event. Program and Faculty are updated daily - check back often for the most up-to-date information. ACR Convergence 2020; 2020 ACR/ARP PRSYM; 2019 ACR/ARP Annual Meeting; 2018 ACR/ARHP Annual Meeting; 2017 ACR/ARHP Annual Meeting; 2017 ACR/ARHP PRSYM; 2016-2009 Meetings; Download Abstracts; Keyword Index; Advanced Search; Your Favorites . Abstract 305. I’ll be covering these topics, and discussing select individual posters and abstracts during this meeting. Abstract 907. One would also take into account whether there is significant skin involvement, as we know that IL-17 and IL-23 inhibitors are superior to TNF inhibitors with respect to the skin. As I mentioned earlier, there are head-to-head studies showing that IL-17 inhibitors are as effective as TNF inhibitors; they are noninferior and superior in the skin. In this case, as well, it wasn’t any different that upadacitinib worked well on the musculoskeletal component of PsA. Efficacy and safety of upadacitinib versus placebo and adalimumab in patients with active psoriatic arthritis and inadequate response to non-biologic disease-modifying anti-rheumatic drugs: a double-blind, randomized controlled phase 3 trial. - And More, Close more info about Expert Insights on Psoriatic Arthritis From ACR Convergence 2020. Approximately 6% to 7% of patients with AS have psoriasis as well. “The Brigham’s Division of Rheumatology, Inflammation, and Immunity provided an important scientific presence at the meeting, and many division members served as moderators and session leaders, contributing significantly to the meeting’s impact and success.”. Ashvattha Therapeutics Selected to Present Virtual Poster at ACR Convergence 2020. The study assessed whether the combination of methotrexate and etanercept was superior to etanercept alone. You’ve viewed {{metering-count}} of {{metering-total}} articles this month. Your use of this website constitutes acceptance of Haymarket Media’s Privacy Policy and Terms & Conditions. Kevin S. Wei, MD, PhD; Ilya Korsunsky, PhD; Jennifer L. Marshall, PhD; Gerald F.M. Type here to filter the list. Thanks for visiting Rheumatology Advisor. All Days; Wed, Nov 4; Thu, Nov 5; Fri, Nov 6; Sat, Nov 7; Sun, Nov 8; Mon, Nov 9; Tue, Nov 10; Sat, Nov 21; Full Schedule - ACR Convergence 2020. However, we do have a biomarker, and that is skin psoriasis. The MAXIMISE study (ClinicalTrials.gov Identifier: NCT02721966) found secukinumab to be effective in patients with axial PsA, so it may not really matter to differentiate between the 2 conditions in day-to-day practice. Favorites; Login; Register; View and print all favorites; Clear all your favorites; Meeting Resource Center; Abstract Number: 1879. Dr Saakshi Khattri reviews key abstracts about psoriatic arthritis from the annual ACR meeting, including a tool for early detection and a study showing dactylitis may signal an aggressive phenotype. The tally included over 120 abstracts: two plenary presentations, 36 oral presentations, one late-breaking poster and 86 poster presentations. If a patient has not responded to treatment with 1 or more TNF inhibitors, then I would probably use IL-17 inhibitors first, only because they have a longer track record compared to the JAK inhibitors. Long-term outcomes with filgotinib, an oral selective Janus kinase 1 inhibitor: 100-week data from an open-label extension (OLE) study in patients with active psoriatic arthritis (PsA). This team targeted schnurri3 (Shn3) — a large, intracellular protein upregulated by TNF and IL-17A and known to be a suppressor of osteoblast activity — in specific bone cells in several mouse models of RA and determined its therapeutic potential in RA-induced bone loss. A couple of head-to-head studies were published in the past year, although not presented at ACR 2020, which compared ixekizumab vs adalimumab and secukinumab vs adalimumab. “This year’s Convergence conference was an historic event, as it was the first fully virtual meeting of the college,” Dr. Gravallese concluded. For PsA, we do not have any antibodies such as rheumatoid factor or anti-CCP. Efficacy of upadacitinib in patients with psoriatic arthritis stratified by number of prior biologic disease-modifying anti-rheumatic drugs. “If we heed these lessons and implement change thoughtfully, rheumatology will enter a new era as an even more essential and highly sought-after specialty,” she said in her speech. Don’t miss out on today’s top content on Rheumatology Advisor. The ACR50/70 responses with deucravacitinib 6 and 12 mg per day administered orally were found to be superior to placebo. SELECT – PsA 1 was a study conducted among biologic-naive patients with PsA, and SELECT – PsA 2 was conducted among patients with PsA who had an inadequate response to treatment with a tumor necrosis factor (TNF) inhibitor. Already have an account? All times listed are Eastern Standard Time. All Days; Wed, Nov 4; Thu, Nov 5; Fri, Nov 6; Sat, Nov 7; Sun, Nov 8; Mon, Nov 9; Tue, Nov 10; Sat, Nov 21; Full Schedule - ACR Convergence 2020. Mease P, Deodhar A, van der Heijde D, et al. Information from the ACR presentations are under embargo until November 5, 2020 … Minimal disease activity with filgotinib was found to be about 31% at week 100.3. It is thought that IL-23 inhibitors have no effect on the axial skeleton based on 2 studies: the first one included risankizumab, another IL-23 p19 inhibitor, and the second one was on ustekinumab, an IL-12/23 inhibitor. Once the posters are made public, they will be available on the Company’s website in the The ACR abstracts are available online at the conference website . One of the new agents for PsA is upadacitinib. The following is a look at five abstracts presented by Brigham physicians and scientists. The only place for free North American stock rankings incorporating insider commitment. Full Schedule - 2020 ACR Convergence. Ellen M. Gravallese, MD, chief of the Brigham’s Division of Rheumatology, Inflammation, and Immunity, gave the Presidential Address upon completion of her term as ACR president, expounding on the inspiring response of ACR members to the COVID-19 pandemic. Highlights of Abstracts From ACR Convergence 2020. Data that will contribute to our decision-making may include considering the severity of musculoskeletal disease, the severity of skin disease, and the safety of the treatment. Abstract Supplement ACR Convergence 2020 - 2020 - Arthritis & Rheumatology - Wiley … The real clinical question is how to differentiate between a patient who has ankylosing spondylitis (AS) with skin psoriasis and a patient who has PsA and axial symptoms. These data were presented earlier at EULAR 2020, but this was the first time they were presented at ACR. ET. However, radiographic examination of these patients will demonstrate symmetric sacroiliitis. I might then consider the IL-12/23 inhibitor ustekinumab because that drug has been in the market for quite some time and it is a very good drug with respect to the skin, although in my experience it is not as good a drug as TNF inhibitors for the joints. The tally included over 120 abstracts: two plenary presentations, 36 oral presentations, one late-breaking poster and 86 poster … However, one has to take this with a “pinch of salt” when one is looking at clinical trials that assess safety, as longer-term follow-up in postmarketing experience is needed. A phase 2 randomized, double-blind, placebo-controlled study evaluated the efficacy and safety of the novel tyrosine kinase type 2 (Tyk2) inhibitor deucravacitinib and was presented in a late-breaking abstract at ACR 2020.6 Tyk2 is part of the Janus kinases. Post was not sent - check your email addresses! Program and Faculty are updated daily - check back often for the most up-to-date information. Presented at: ACR Convergence 2020; November 5-9, 2020. RA is a chronic inflammatory disease that leads to local and systemic bone loss. However, there was a significant ACR50/70 response in patients who received methotrexate alone. Mease P, Lertratanakul A, Strober B, et al. It is very important to assess the patients’ status in terms of how comfortable they are with the route of administration (oral vs injection), their risk tolerance, their insurance, etc. Posted on 10/27/2020 0 . There was also a slight dose response with the 12-mg dose being slightly better than the 6-mg dose, although the difference between the 2 doses did not reach statistical significance. Sorry, your blog cannot share posts by email. Shared decision-making is very important. These “checkpoint inhibitor” therapies can unleash a powerful immune response against tumors but can also induce unintended autoimmune responses, including inflammatory arthritis. For many clinical trials in rheumatology, identifying eligible patients is a labor-intensive and rate-limiting step. … Full Schedule - ACR Convergence 2020; Full Schedule - ACR Convergence 2020. - Case Studies At 5 years, it became challenging to identify what the risk factors were, although 1 risk factor that stood out was nail disease at baseline, which was something we already knew. Haberman R, Perez-Chada L, Chandran V, et al. The work provided promising evidence that targeting this pathway could be a novel therapeutic strategy for both systemic and joint-based RA-induced bone loss. Last year, ACR and the National Psoriasis Foundation (NPF) published treatment guidelines, which are the latest guidelines available to us. All times listed are Eastern Standard Time. Gravallese and Solomon lamented the inability to interact directly with fellow participants but noted an upside: About 16,400 people from 111 countries attended at least some portion of the conference, compared with the typical 9,000 to 10,000 attendees. The study concluded that there is a high burden of these needs among medically and psychosocially complex patients with lupus and that iCMP can successfully uncover and begin to address these barriers to care. Currently, there is no good way of defining axial PsA, although the Assessment of SpA International Society (ASAS) and the Group for Research and Assessment of Psoriasis and PsA (GRAPPA) are conducting a larger international study, the Axial Involvement in PsA Cohort (AXIS) study (ClinicalTrials.gov Identifier: NCT04434885), to define axial PsA and how to quantify these patients. Approximately 80% of patients with AS have the HLA-B27 gene, and only approximately 50% of patients with axial PsA have the HLA-B27. Type here to filter the list. Type here to filter the list. They also evaluated individual components of BASDAI.4 These findings are quite interesting and make us think that perhaps axial PsA is different than axial SpA. Abstract LO3. There are many differences in the presentation of these patients. Register for free and gain unlimited access to: - Clinical News, with personalized daily picks for you Abstract Supplement ACR Convergence 2020. Jessica N. Williams, MD, MPH; Kreager Taber; Candace H. Feldman, MD. - Drug Monographs Results of the SEAM study (Etanercept and Methotrexate in Combination or as Monotherapy in Psoriatic Arthritis; ClinicalTrials.gov Identifier: NCT02376790) were published last year and presented at the 2019 ACR annual meeting. … Program and Faculty are updated daily - check back often for the most up-to-date information. At 1 year, predictors of development of PsA included arthralgia, joint aches and pains, and fatigue. ACR CONVERGENCE 2020—Moderated by Bill St.Clair, MD, MACR, an ACR past president and a professor of medicine and immunology at Duke University Medical Center, Durham, N.C., an abstract session on Friday, Nov. 6, focused on the diagnosis, manifestations and outcomes of rheumatoid arthritis (RA), with a focus on interstitial lung disease. At the ACR Convergence 2020, updated findings were presented for weeks 52 to 92 in patients who continued ADL-PF (N = 552). Efficacy of guselkumab, a monoclonal antibody that specifically binds to the p19 subunit of il-23, on axial-related endpoints in patients with active psa with imaging-confirmed sacroiliitis: week-52 results from two phase 3, randomized, double-blind, placebo-controlled studies. Home of the insider insights newsletter and the Canadian Insider Club which offers alerts and premium research. - Conference Coverage ACR CONVERGENCE 2020— Earlier this year, the ACR released an updated guideline for the management of gout, and approximately 50 abstracts of studies on various aspects of gout were accepted for presentation at ACR Convergence 2020. They also aimed to understand whether social determinants of health-related needs such as food insecurity, housing instability and financial constraints were prevalent among patients with lupus enrolled in iCMP. There were several interesting abstracts presented at this year’s ACR annual meeting from a therapy standpoint, some of which were also presented at the 2020 European League Against Rheumatism (EULAR) annual meeting. There is a lot of work being conducted on standardizing the terminology for pre-PsA. There were 2 phase 3 studies presented at ACR 2020: SELECT – PsA 1 (ClinicalTrials.gov Identifier: NCT03104400) and SELECT – PsA 2 (ClinicalTrials.gov Identifier: NCT03104374). The American College of Rheumatology’s annual Convergence conference, which took place Nov. 5–9, featured significant contributions from Brigham and Women’s Hospital physicians and scientists. At week 52, all patients remaining on ADL-EU were switched to ADL-PF. Investigators said efficacy response rates at week 78 were 84.2% for all patients, and 83.4%, 85.8%, and 84.3% for the biosimilar, week 26 switch, and week 52 switch groups, respectively. Two long-time Brigham rheumatologists also received prestigious honors. Dr. Rao led a team that used mass cytometry immunophenotyping to study the immune cells that accumulate in joint fluid of patients who develop inflammatory arthritis following anti-PD-1 therapy. ACR CONVERGENCE 2020—The field of rheumatology is vast, with innumerable diseases to consider in each differential and with myriad possible presentations of each condition. Abstract 1356. A presentation at ACR 2020 looked at the terminology in detail.5 In addition, there is an organization, PPACMAN (the Psoriasis & Psoriatic Arthritis Clinics Multicenter Advancement Network), in the United States that includes clinics in dermatology and rheumatology that is exploring pre-PsA terminology because unless these patients are defined carefully, it becomes challenging to study their condition. Interesting poster and Abstract presentations on spondyloarthritis at the end of 2021 researchers of the guselkumab! Heijde D, et al, radiographic examination of these abstracts, please visit.. Check your email addresses population of CD38hi CD8+ t cells that accumulated the. Clear all your favorites ; Clear all your favorites ; Meeting Resource Center ; ACR Convergence 2020 ; 5-9... 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Time, ACR and the Canadian insider Club which offers alerts and premium research and Abstract presentations spondyloarthritis. Received methotrexate alone L. Marshall, PhD ; Gerald F.M der Heijde D, et al study also included as! Etanercept alone released at the conference website wish to read SEC and insider!

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